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How Kobe Died

The KO (KEGG Orthology) database is a database of molecular functions represented in terms of functional orthologs. A functional ortholog is manually defined in the context of KEGG molecular networks, namely, KEGG pathway maps, BRITE hierarchies and KEGG modules. Each node of the network, such as a box in the KEGG pathway map, is given a KO identifier (called K number) as a functional ortholog defined from experimentally characterized genes and proteins in specific organisms, which are then used to assign orthologous genes in other organisms based on sequence similarity. The granularity of 'function' is context-dependent, and the resulting KO grouping may correspond to a group of highly similar sequences within a limited organism group or it may be a more divergent group.
The KO system is a network-based classification of KOs shown below:
KEGG Orthology (KO)
It consists of six top categories (09100 to 09160) for KEGG pathway maps and one top category (09180) for BRITE hierarchies, as well as one top category (09190) for those KOs that are not yet included in either of them. The category numbers for these top categories and the second-level categories under metabolism (09101 to 09112) are used to define color coding of functions (see KEGG Color Codes).
Major efforts have been made to associate each KO entry with experimental evidence of functionally characterized sequence data as shown in the SEQUENCE subfield of the REFERENCE field. In many cases such data are not found in the complete genomes of KEGG organisms. The addendum category of the GENES database allows functionally characterized individual protein sequences to be included in KEGG. As a byproduct of these efforts, sequence data have also been associated with EC numbers in Enzyme Nomenclature.